Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0C6PS
|
|||
| Former ID |
DAP001301
|
|||
| Drug Name |
Muromonab
|
|||
| Indication | Organ transplant rejection [ICD-11: NE84; ICD-9: 279.5, 996] | Approved | [1] | |
| Therapeutic Class |
Immunomodulatory Agents
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | T-cell surface glycoprotein CD3 epsilon (CD3E) | Target Info | Binder | [2] |
| KEGG Pathway | Hematopoietic cell lineage | |||
| T cell receptor signaling pathway | ||||
| Chagas disease (American trypanosomiasis) | ||||
| Measles | ||||
| HTLV-I infection | ||||
| Primary immunodeficiency | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Leptin Signaling Pathway | ||||
| Panther Pathway | T cell activation | |||
| Pathway Interaction Database | TCR signaling in naï | |||
| IL12-mediated signaling events | ||||
| TCR signaling in naï | ||||
| CXCR4-mediated signaling events | ||||
| IL23-mediated signaling events | ||||
| Downstream signaling in naï | ||||
| IL12 signaling mediated by STAT4 | ||||
| Reactome | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | |||
| Phosphorylation of CD3 and TCR zeta chains | ||||
| Translocation of ZAP-70 to Immunological synapse | ||||
| Generation of second messenger molecules | ||||
| PD-1 signaling | ||||
| WikiPathways | TCR Signaling Pathway | |||
| TCR signaling | ||||
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
| Costimulation by the CD28 family | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 2 | Basiliximab: a review of its use as induction therapy in renal transplantation. Drugs. 2003;63(24):2803-35. | |||
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