Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0C4BL
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| Former ID |
DNCL002583
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| Drug Name |
Coxsackievirus A21
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| Synonyms |
Cavatak (TN)
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|
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| Indication | Glioblastoma multiforme [ICD-11: 2A00.0; ICD-9: 191] | Phase 2 | [1] | |
| Bladder cancer [ICD-11: 2C94; ICD-9: 188] | Phase 1/2 | [2] | ||
| Lung cancer [ICD-11: 2C25.0; ICD-9: 162] | Phase 1/2 | [2] | ||
| Melanoma [ICD-11: 2C30; ICD-9: 172] | Phase 1/2 | [2] | ||
| Prostate cancer [ICD-11: 2C82.0; ICD-10: C61; ICD-9: 185] | Phase 1/2 | [2] | ||
| Company |
Viralytics
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Complement decay-accelerating factor (CD55) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Complement and coagulation cascades | |||
| Hematopoietic cell lineage | ||||
| Viral myocarditis | ||||
| NetPath Pathway | IL5 Signaling Pathway | |||
| IL2 Signaling Pathway | ||||
| FSH Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | ||||
| Reactome | Class B/2 (Secretin family receptors) | |||
| Regulation of Complement cascade | ||||
| WikiPathways | Complement and Coagulation Cascades | |||
| Complement Activation, Classical Pathway | ||||
| Human Complement System | ||||
| GPCR ligand binding | ||||
| Complement cascade | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Oncolytic Coxsackievirus A21 as a novel therapy for multiple myeloma. Br J Haematol. 2007 Apr;137(2):133-41. | |||
| REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
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