Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0C4BD
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| Former ID |
DIB010022
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| Drug Name |
KH-901
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| Synonyms |
Comfeagen; GM-CSF gene-carrying recombinant adenovirus vaccine (solid tumor), Kanghong Biotechnologies
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| Drug Type |
Vaccine
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [1] | |
| Company |
Chengdu Kanghong Biotechnologies Co Ltd
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GMCSFR-alpha (CSF2RA) | Target Info | . | [2] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Jak-STAT signaling pathway | ||||
| Hematopoietic cell lineage | ||||
| Pathways in cancer | ||||
| NetPath Pathway | IL3 Signaling Pathway | |||
| RANKL Signaling Pathway | ||||
| Pathway Interaction Database | GMCSF-mediated signaling events | |||
| Alpha9 beta1 integrin signaling events | ||||
| Reactome | GPVI-mediated activation cascade | |||
| G beta:gamma signalling through PI3Kgamma | ||||
| Interleukin-3, 5 and GM-CSF signaling | ||||
| RAF/MAP kinase cascade | ||||
| Surfactant metabolism | ||||
| Interleukin receptor SHC signaling | ||||
| WikiPathways | Interleukin-2 signaling | |||
| Interleukin-3, 5 and GM-CSF signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A Phase I study of KH901, a conditionally replicating granulocyte-macrophage colony-stimulating factor: armed oncolytic adenovirus for the treatmen... Cancer Biol Ther. 2009 Apr;8(8):676-82. | |||
| REF 2 | Effects of KH901, a tumor-specific oncolytic recombinant adenovirus, on antitumor and expressing GM-CSF in xenograft tumor models. Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Jun;38(3):386-90. | |||
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