Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0C2UY
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| Former ID |
DNC003506
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| Drug Name |
MANUMYCIN A
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| Synonyms |
manumycin; Manumycin A; Ucfi-C; UNII-OIQ298X4XD; AC1O5PHE; OIQ298X4XD; CHEBI:29623; C31H38N2O7; 52665-74-4; 2,4-Decadienamide, N-(5-hydroxy-5-(7-((2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino)-7-oxo-1,3,5-heptatrienyl)-2-oxo-7-oxabicyclo(4.1.0)hept-3-en-3-yl)-2,4,6-trimethyl-; (2E,4E,6R)-N-[(1S,5S,6R)-5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxo-cyclopenten-1-yl)amino]-7-oxo-hepta-1,3,5-trienyl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-2,4,6-trimethyl-deca-2,4-dienamide; ( )-Manumycin A; BSPBio_001231; SCHEMBL12519093
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| Drug Type |
Small molecular drug
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| Structure |
 |
Download2D MOL |
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| Formula |
C31H38N2O7
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| Canonical SMILES |
CCCCC(C)C=C(C)C=C(C)C(=O)NC1=CC(C2C(C1=O)O2)(C=CC=CC=CC(=O)NC3=C(CCC3=O)O)O
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| InChI |
1S/C31H38N2O7/c1-5-6-11-19(2)16-20(3)17-21(4)30(38)32-22-18-31(39,29-28(40-29)27(22)37)15-10-8-7-9-12-25(36)33-26-23(34)13-14-24(26)35/h7-10,12,15-19,28-29,34,39H,5-6,11,13-14H2,1-4H3,(H,32,38)(H,33,36)/b8-7+,12-9+,15-10+,20-16+,21-17+/t19-,28-,29-,31+/m1/s1
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| InChIKey |
TWWQHCKLTXDWBD-MVTGTTCWSA-N
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| CAS Number |
CAS 52665-74-4
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:29623
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | CAAX farnesyltransferase beta (FNTB) | Target Info | Inhibitor | [1] |
| Farnesyl protein transferase (Ftase) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Terpenoid backbone biosynthesis | |||
| Biosynthesis of antibiotics | ||||
| NetPath Pathway | TSH Signaling Pathway | |||
| Reactome | Inactivation, recovery and regulation of the phototransduction cascade | |||
| WikiPathways | Visual phototransduction | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A novel metal-chelating inhibitor of protein farnesyltransferase. Bioorg Med Chem Lett. 2003 May 5;13(9):1523-6. | |||
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