Drug Information
Drug General Information | Top | |||
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Drug ID |
D0C2KS
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Former ID |
DIB019132
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Drug Name |
CI-1015
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Synonyms |
CI 1015; PD 144598; CI1015
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C29H39N3O4
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Canonical SMILES |
CC(CC1=CNC2=CC=CC=C21)(C(=O)NC3CCCCC3O)NC(=O)OC45CC6CC(C4)CC(C6)C5
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InChI |
1S/C29H39N3O4/c1-28(26(34)31-24-8-4-5-9-25(24)33,16-21-17-30-23-7-3-2-6-22(21)23)32-27(35)36-29-13-18-10-19(14-29)12-20(11-18)15-29/h2-3,6-7,17-20,24-25,30,33H,4-5,8-16H2,1H3,(H,31,34)(H,32,35)/t18?,19?,20?,24-,25-,28+,29?/m0/s1
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InChIKey |
UOFRODPUIMDZTB-HDCXSGMISA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Cholecystokinin receptor type A (CCKAR) | Target Info | Antagonist | [2] |
Gastrin/cholecystokinin type B receptor (CCKBR) | Target Info | Antagonist | [2] | |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Gastric acid secretion | ||||
Insulin secretion | ||||
Pancreatic secretion | ||||
Panther Pathway | CCKR signaling map ST | |||
Pathwhiz Pathway | Gastric Acid Production | |||
Reactome | Peptide ligand-binding receptors | |||
G alpha (q) signalling events | ||||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
Secretion of Hydrochloric Acid in Parietal Cells | ||||
Peptide GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 872). | |||
REF 2 | Second generation "peptoid" CCK-B receptor antagonists: identification and development of N-(adamantyloxycarbonyl)-alpha-methyl-(R)-tryptophan derivative (CI-1015) with an improved pharmacokinetic profile. J Med Chem. 1998 Jan 1;41(1):38-45. |
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