Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D0C0KJ
|
|||
Former ID |
DIB020247
|
|||
Drug Name |
LTE4
|
|||
Synonyms |
Leukotriene E4; leukotriene E4; Leukotriene E; UNII-8EYT8ATL7G; 75715-89-8; 8EYT8ATL7G; CHEMBL509456; CHEBI:15650; OTZRAYGBFWZKMX-FRFVZSDQSA-N; 5S-hydroxy,6R-(S-cysteinyl),7E,9E,11Z,14Z-eicosatetraenoic acid; C23H37NO5S; (5S-(5R*,6S*(S*),7E,9E,11Z,14Z))-6-((2-Amino-2-carboxyethyl)thio)-5-hydroxy-7,9,11,14-eicosatetraenoic acid; (5S,6R,7E,9E,11Z,14Z)-6-[(2R)-2-amino-3-hydroxy-3-oxopropyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid; [3H]LTE4; AC1NQXPM; LEUKOTRIEN E4; BSPBio_001370; leukotriene E
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
Structure |
Download2D MOL
|
|||
Formula |
C23H37NO5S
|
|||
Canonical SMILES |
CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)O)N
|
|||
InChI |
1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1
|
|||
InChIKey |
OTZRAYGBFWZKMX-FRFVZSDQSA-N
|
|||
CAS Number |
CAS 75715-89-8
|
|||
PubChem Compound ID | ||||
PubChem Substance ID |
8236, 4266070, 7979753, 8143276, 8616419, 16344702, 26756770, 39289868, 48409442, 50111414, 57357904, 74701367, 96099805, 103591347, 104138918, 113854149, 127316814, 127316815, 127316816, 127316817, 127316818, 135651514, 137006567, 138355247, 164228112, 164761568, 178102487, 179293257, 198951720, 198991667, 236466655, 250135039, 252455510, 252467954
|
|||
ChEBI ID |
CHEBI:15650
|
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Leukotriene CysLT1 receptor (CYSLTR1) | Target Info | Agonist | [3] |
Leukotriene CysLT2 receptor (CYSLTR2) | Target Info | Agonist | [4] | |
Oxoglutarate receptor (OXGR1) | Target Info | Agonist | [5] | |
Uracil nucleotide/cysteinyl leukotriene receptor (GPR17) | Target Info | Agonist | [6] | |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
IL4 Signaling Pathway | ||||
IL3 Signaling Pathway | ||||
Pathway Interaction Database | Endothelins | |||
Reactome | Leukotriene receptors | |||
G alpha (q) signalling events | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
---|---|---|---|---|
REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5863). | |||
REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3352). | |||
REF 3 | Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature. 1999 Jun 24;399(6738):789-93. | |||
REF 4 | Differential signaling of cysteinyl leukotrienes and a novel cysteinyl leukotriene receptor 2 (CysLT agonist, N-methyl-leukotriene C in calcium reporter and beta arrestin assays. Mol Pharmacol. 2011 Feb;79(2):270-8. | |||
REF 5 | Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand. J Biol Chem. 2013 Apr 19;288(16):10967-72. | |||
REF 6 | The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. PLoS One. 2008;3(10):e3579. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.