Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0B8YZ
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| Former ID |
DNC012877
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| Drug Name |
ELTANOLONE
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| Synonyms |
Pregnanolone; 3alpha-Hydroxy-5beta-pregnan-20-one; 128-20-1; Pregnanolone II; Pregnan-3alpha-ol-20-one; Eltanolona; Eltanolonum; 5beta-Pregnan-3alpha-ol-20-one; Eltanolone [INN]; SKF 6455; NSC 82867; UNII-BXO86P3XXW; Eltanolonum [INN-Latin]; Eltanolona [INN-Spanish]; Allopregnan-3 beta-ol-20-one; (3alpha,5beta)-3-hydroxypregnan-20-one; 3alpha-Hydroxy-5beta-tetrahydroprogesterone; 3alpha,5beta-Epimeric pregnanolone; Pregnanolone, (3alpha,5beta)-isomer; BXO86P3XXW
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| Drug Type |
Small molecular drug
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| Indication | Premenstrual syndrome [ICD-11: GA34.40; ICD-10: N94.3] | Discontinued in Phase 3 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C21H34O2
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| Canonical SMILES |
CC(=O)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)O)C)C
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| InChI |
1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15-,16+,17-,18+,19+,20+,21-/m1/s1
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| InChIKey |
AURFZBICLPNKBZ-YZRLXODZSA-N
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| CAS Number |
CAS 128-20-1
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:1712
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor alpha-1 (GABRA1) | Target Info | Inhibitor | [2] |
| GABA(A) receptor beta-2 (GABRB2) | Target Info | Inhibitor | [2] | |
| GABA(A) receptor gamma-2 (GABRG2) | Target Info | Inhibitor | [2] | |
| Gamma-aminobutyric acid receptor (GAR) | Target Info | Inhibitor | [3] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Serotonergic synapse | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005875) | |||
| REF 2 | Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (... J Med Chem. 2005 Apr 21;48(8):3051-9. | |||
| REF 3 | Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. J Med Chem. 2006 Jul 27;49(15):4595-605. | |||
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