Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0B5KE
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| Former ID |
DIB006919
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| Drug Name |
EB-1053
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| Synonyms |
EB 1053; 125946-92-1; Disodium 1-hydroxy-3-(1-pyrrolidinyl)propylidene-1,1-bisphosphonate; AC1L2Y2V; SCHEMBL3067217; DTXSID20154998; Phosphonic acid, (1-hydroxy-3-(1-pyrrolidinyl)propylidene)bis-, disodium salt; disodium (1-hydroxy-1-phosphonato-3-pyrrolidin-1-ylpropyl)phosphonic acid
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| Drug Type |
Small molecular drug
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| Indication | Osteoporosis [ICD-11: FB83.0; ICD-10: M85.8] | Discontinued in Phase 2 | [1] | |
| Company |
LEO Pharma A/S
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| Structure |
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Download2D MOL |
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| Formula |
C7H17NO7P2
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| Canonical SMILES |
C1CCN(C1)CCC(O)(P(=O)(O)O)P(=O)(O)O
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| InChI |
1S/C7H17NO7P2/c9-7(16(10,11)12,17(13,14)15)3-6-8-4-1-2-5-8/h9H,1-6H2,(H2,10,11,12)(H2,13,14,15)
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| InChIKey |
PMXAPNNYCFBALB-UHFFFAOYSA-N
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| CAS Number |
CAS 125946-92-1
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bone resorption factor (BRF) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006406) | |||
| REF 2 | Disodium 1-hydroxy-3-(1-pyrrolidinyl)-propylidene-1,1-bisphosphonate (EB-1053) is a potent inhibitor of bone resorption in vitro and in vivo. J Bone Miner Res. 1992 Aug;7(8):981-6. | |||
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