Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0B3UJ
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| Former ID |
DIB004838
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| Drug Name |
Paliperidone
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| Synonyms |
Xeplion; Invega Sustenna; Paliperidone palmitate; JNS-010; Paliperidone (depot injection, NanoCrystal); Paliperidone (injectable, NanoCrystal), Elan; Paliperidone (depot injection, NanoCrystal), Johnson & Johnson
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| Drug Type |
Small molecular drug
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| Indication | Schizophrenia [ICD-11: 6A20] | Approved | [1], [2], [3] | |
| Company |
Johnson & Johnson
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| Structure |
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Download2D MOL |
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| Formula |
C23H27FN4O3
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| Canonical SMILES |
CC1=C(C(=O)N2CCCC(C2=N1)O)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
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| InChI |
1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3
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| InChIKey |
PMXMIIMHBWHSKN-UHFFFAOYSA-N
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| CAS Number |
CAS 144598-75-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
10236700, 14905143, 22395187, 29296762, 46506296, 47207025, 50035150, 51002222, 57339070, 85229944, 85246150, 90341688, 92719038, 92729808, 103604037, 103910909, 104105311, 104397925, 118046559, 121361150, 125307525, 125341102, 126584511, 126621140, 126649064, 126650388, 126667060, 128939139, 131465791, 131549340, 134338126, 135072932, 136367845, 137166111, 142528484, 144116334, 152258953, 152344196, 160647798, 160810375, 160964597, 162185890, 163088563, 163371020, 163564516, 163981461, 164175255, 164785605, 170501956, 171063034
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| ChEBI ID |
CHEBI:83804
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| ADReCS Drug ID | BADD_D01656 ; BADD_D01657 | |||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Alistipes indistinctus DSM22520
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Paliperidone can be metabolized by Alistipes indistinctus DSM22520 (log2FC = -0.837; p = 0.027). | |||
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Studied Microbe: Bacteroides caccae ATCC 43185
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Paliperidone can be metabolized by Bacteroides caccae ATCC 43185 (log2FC = -0.679; p = 0.02). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Paliperidone can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -0.653; p = 0.024). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium breve DSM 20213
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Paliperidone can be metabolized by Bifidobacterium breve DSM 20213 (log2FC = -0.656; p = 0.045). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella intestinalis DSM 13280
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Paliperidone can be metabolized by Collinsella intestinalis DSM 13280 (log2FC = -0.519; p = 0.041). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Enterobacter cancerogenus ATCC35316
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Paliperidone can be metabolized by Enterobacter cancerogenus ATCC35316 (log2FC = -0.658; p = 0.009). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Anaerotruncus colihominis DSM 17241
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Paliperidone can be metabolized by Anaerotruncus colihominis DSM 17241 (log2FC = -1.104; p = 0.013). | |||
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Studied Microbe: Blautia luti DSM 14534
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Paliperidone can be metabolized by Blautia luti DSM 14534 (log2FC = -1.545; p = 0.037). | |||
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Studied Microbe: Clostridium asparagiforme DSM 15981
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Paliperidone can be metabolized by Clostridium asparagiforme DSM 15981 (log2FC = -1.963; p = 0.018). | |||
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Studied Microbe: Clostridium scindens ATCC 35704
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Paliperidone can be metabolized by Clostridium scindens ATCC 35704 (log2FC = -0.757; p = 0.008). | |||
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Studied Microbe: Clostridium sporogenes ATCC 15579
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Paliperidone can be metabolized by Clostridium sporogenes ATCC 15579 (log2FC = -4.821; p = 0.022). | |||
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Studied Microbe: Clostridium symbiosum ATCC 14940
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Paliperidone can be metabolized by Clostridium symbiosum ATCC 14940 (log2FC = -0.732; p = 0.018). | |||
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Studied Microbe: Coprococcus comes ATCC 27758
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Paliperidone can be metabolized by Coprococcus comes ATCC 27758 (log2FC = -2.777; p = 0.003). | |||
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Studied Microbe: Eubacterium hallii DSM3353
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Paliperidone can be metabolized by Eubacterium hallii DSM3353 (log2FC = -2.94; p = 0.012). | |||
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Studied Microbe: Eubacterium rectale ATCC 33656
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Paliperidone can be metabolized by Eubacterium rectale ATCC 33656 (log2FC = -1.171; p = 0.012). | |||
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Studied Microbe: Roseburia intestinalis L1-82
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Paliperidone can be metabolized by Roseburia intestinalis L1-82 (log2FC = -2.231; p = 0.019). | |||
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Studied Microbe: Ruminococcus lactaris ATCC 29176
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Paliperidone can be metabolized by Ruminococcus lactaris ATCC 29176 (log2FC = -0.59; p = 0.009). | |||
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Studied Microbe: Subdoligranulum variabile DSM 15176
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Paliperidone can be metabolized by Subdoligranulum variabile DSM 15176 (log2FC = -1.133; p = 0.023). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Tissierellales | ||||
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Studied Microbe: Anaerococcus hydrogenalis DSM 7454
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Paliperidone can be metabolized by Anaerococcus hydrogenalis DSM 7454 (log2FC = -3.405; p = 0.005). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Gut microbiota unspecific | [5] | |||
| Metabolic Reaction | Hydrolysis of isoxazole | |||
| Experimental Method | High-throughput screening | |||
| Description | Paliperidone can be metabolized by gut microbiota through hydrolysis of isoxazole. | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT receptor (5HTR) | Target Info | Antagonist | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7258). | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 3 | ClinicalTrials.gov (NCT02146547) European Long-acting Antipsychotics in Schizophrenia Trial. U.S. National Institutes of Health. | |||
| REF 4 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 5 | Personalized Mapping of Drug Metabolism by the Human Gut Microbiome. Cell. 2020 Jun 25;181(7):1661-1679.e22. | |||
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