Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0B1PC
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| Former ID |
DIB016951
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| Drug Name |
OXECLOSPORIN
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| Synonyms |
Lic amide; IMM-125; Oxeclosporin; SDZ-IMM-125; Yl-(N-methyl)valine cyclic lactam; [3-O-(2-Hydroxyethyl)-D-seryl]8-cyclosporin; 3(R)-Hydroxy-4(R)-methyl-2(S)-(methylamino)-6(E)-octenoyl-2(S)-aminobutyryl-(N-methyl)glycyl-(N-methyl)leucyl-valyl-(N-methyl)leucyl-alanyl-[O-(2-hydroxyethyl)]-D-seryl-(N-methyl)leucyl-(N-methyl)leuc; 4(R)-[2(E)-Butenyl]-N,4-dimethyl-threonyl-(2-aminobutyryl)-sarcosyl-N-methyl-leucyl-valyl-N-methyl-leucyl-alanyl-[3-O-(2-hydroxyethyl)]-D-seryl-N-methyl-leucyl-N-methyl-leucyl-N-methyl-valine 1,11-cyc
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| Indication | Immune System disease [ICD-11: 4A01-4B41; ICD-10: T86.0] | Discontinued in Phase 1 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C64H115N11O14
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| Canonical SMILES |
CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)COCCO)C)CC(C)C)C)C(C)C)CC(C)C)C)C
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| InChI |
1S/C64H115N11O14/c1-24-26-27-42(15)54(78)53-58(82)66-44(25-2)59(83)69(17)34-50(77)70(18)46(30-36(3)4)57(81)68-51(40(11)12)63(87)71(19)47(31-37(5)6)56(80)65-43(16)55(79)67-45(35-89-29-28-76)60(84)72(20)48(32-38(7)8)61(85)73(21)49(33-39(9)10)62(86)74(22)52(41(13)14)64(88)75(53)23/h24,26,36-49,51-54,76,78H,25,27-35H2,1-23H3,(H,65,80)(H,66,82)(H,67,79)(H,68,81)/b26-24+/t42-,43+,44+,45-,46+,47+,48+,49+,51+,52+,53+,54-/m1/s1
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| InChIKey |
XZDDMPMZGYEESG-VNHFGJPGSA-N
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| CAS Number |
CAS 135548-15-1
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| PubChem Compound ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002453) | |||
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