Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0B0UN
|
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| Former ID |
DCL000617
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| Drug Name |
R7232
|
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| Indication | Dyslipidemia [ICD-11: 5C80-5C81; ICD-9: 272] | Discontinued in Phase 1 | [1] | |
| Company |
Roche
|
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| Structure |
 |
Download2D MOL |
||
| Formula |
C7H9ClN2O
|
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| Canonical SMILES |
CC1=C(C(=NN1C)C)C(=O)Cl
|
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| InChI |
1S/C7H9ClN2O/c1-4-6(7(8)11)5(2)10(3)9-4/h1-3H3
|
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| InChIKey |
UFNVZQRBSDFSPY-UHFFFAOYSA-N
|
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| CAS Number |
CAS 98298-63-6
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cholesteryl ester transfer protein (CETP) | Target Info | Inhibitor | [2], [3] |
| Panther Pathway | CCKR signaling map ST | |||
| Reactome | LDL-mediated lipid transport | |||
| HDL-mediated lipid transport | ||||
| WikiPathways | Statin Pathway | |||
| Lipid digestion, mobilization, and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027351) | |||
| REF 2 | Clinical pipeline report, company report or official report of Roche (2009). | |||
| REF 3 | Phase 2 study of bosutinib, a Src inhibitor, in adults with recurrent glioblastoma. J Neurooncol. 2015 Feb;121(3):557-63. | |||
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