Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0AV3G
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| Former ID |
DAP000317
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| Drug Name |
Domperidone
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| Synonyms |
Domperidon; Domperidona; Domperidonum; Motilium; Nauzelin; KW 5338; NCI299589; Costi (TN); D-122; Domperidona [INN-Spanish]; Domperidonum [INN-Latin]; HS-0067; KW-5338; Motilium (TN); Motillium (TN); Motinorm (TN); R 33,812; R-33812; R-33,812; Domperidone (JAN/USAN/INN); Domperidone [USAN:BAN:INN:JAN]; 4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine; 5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone; 5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one; 5-Chloro-1-[1-[3-(2-oxo-1-benzimidazolinyl)propyl]-4-piperidyl]-2-benzimidazolinone; 5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one; 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one; 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one
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| Drug Type |
Small molecular drug
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| Indication | Gastrointestinal disease [ICD-11: DE2Z] | Approved | [1], [2] | |
| Therapeutic Class |
Antiemetics
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| Company |
Janssen Pharmaceutica
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| Structure |
 |
Download2D MOL |
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| Formula |
C22H24ClN5O2
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| Canonical SMILES |
C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O
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| InChI |
1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)
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| InChIKey |
FGXWKSZFVQUSTL-UHFFFAOYSA-N
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| CAS Number |
CAS 57808-66-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
147912, 855562, 4254117, 4396595, 7848808, 7979120, 8141008, 8152006, 10320029, 10321742, 11111029, 11342096, 11362279, 11363285, 11365847, 11368409, 11373493, 11376571, 11406905, 11459105, 11461219, 11466489, 11467609, 11486237, 11487681, 11491902, 11494205, 12013334, 14856268, 17404990, 24277911, 26613181, 26653336, 26746912, 26746913, 26751449, 29222293, 46500486, 46508314, 47216928, 47291272, 47291273, 47959936, 48334655, 48334656, 48334657, 49698821, 49883248, 50085997, 50103922
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| ChEBI ID |
CHEBI:31515
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| ADReCS Drug ID | BADD_D00705 | |||
| SuperDrug ATC ID |
A03FA03
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| SuperDrug CAS ID |
cas=057808669
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 965). | |||
| REF 2 | A systematic review of the efficacy of domperidone for the treatment of diabetic gastroparesis. Clin Gastroenterol Hepatol. 2008 Jul;6(7):726-33. | |||
| REF 3 | Screening of domperidone in wastewater by high performance liquid chromatography and solid phase extraction methods. Talanta. 2006 Jan 15;68(3):928-31. | |||
| REF 4 | The significance of disordered gastric emptying. Z Gastroenterol. 1986 Sep;24 Suppl 2:45-54. | |||
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