Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0AS0V
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| Former ID |
DNC000075
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| Drug Name |
5,8-Dihydroxy-1,4-naphthoquinone
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| Synonyms |
Naphthazarin; 475-38-7; Naphthazarine; 5,8-dihydroxynaphthalene-1,4-dione; Naphthazarone; 5,8-Dihydroxynaphthoquinone; 5,8-Dihydroxy-1,4-naphthalenedione; NAPHTHAZALIN; 5,8-Dihydroxynaphthalene-1,4(4aH,8aH)-dione; 5,8-Dihydroxy-1,4-naphthosemiquinone; CCRIS 6670; Dihydroxynaphthoquinone; EINECS 207-495-4; NSC 26647; UNII-S9IX5I5C0K; S9IX5I5C0K; CHEMBL274056; CHEBI:28849; 1,4-NAPHTHOQUINONE, 5,8-DIHYDROXY-; NSC26647; 5,8-Dihydroxy-[1,4]naphthoquinone; NSC344555
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| Drug Type |
Small molecular drug
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| Indication | Malaria [ICD-11: 1F40-1F45; ICD-10: B50-B64, B54] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C10H6O4
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| Canonical SMILES |
C1=CC(=C2C(=O)C=CC(=O)C2=C1O)O
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| InChI |
1S/C10H6O4/c11-5-1-2-6(12)10-8(14)4-3-7(13)9(5)10/h1-4,11-12H
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| InChIKey |
RQNVIKXOOKXAJQ-UHFFFAOYSA-N
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| CAS Number |
CAS 475-38-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
87461, 462245, 600875, 3139046, 5993811, 8002799, 8141348, 8157311, 10523704, 11406536, 12055839, 15195312, 24863527, 24864236, 29228673, 49996645, 50946193, 53788508, 57325989, 87568519, 88832055, 93375160, 103143269, 103171933, 103857292, 103956510, 104322490, 117587016, 118315894, 125351143, 126688756, 129167442, 134221048, 134339612, 134348675, 134973316, 137007696, 139901813, 143439363, 143855503, 152054401, 160798042, 162147071, 162185777, 162219821, 162292918, 162858406, 163396742, 164805001, 175444392
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| ChEBI ID |
CHEBI:28849
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Arachidonate 5-lipoxygenase (5-LOX) | Target Info | Inhibitor | [2] |
| Cytoplasmic thioredoxin reductase (TXNRD1) | Target Info | Inhibitor | [1] | |
| BioCyc | Aspirin-triggered lipoxin biosynthesis | |||
| Resolvin D biosynthesis | ||||
| Leukotriene biosynthesis | ||||
| Lipoxin biosynthesis | ||||
| Aspirin triggered resolvin D biosynthesis | ||||
| Aspirin triggered resolvin E biosynthesis | ||||
| KEGG Pathway | Arachidonic acid metabolism | |||
| Metabolic pathways | ||||
| Serotonergic synapse | ||||
| Ovarian steroidogenesis | ||||
| Toxoplasmosis | ||||
| NetPath Pathway | IL4 Signaling Pathway | |||
| Pathwhiz Pathway | Arachidonic Acid Metabolism | |||
| WikiPathways | Vitamin D Receptor Pathway | |||
| Arachidonic acid metabolism | ||||
| Eicosanoid Synthesis | ||||
| Selenium Micronutrient Network | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10. | |||
| REF 2 | Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem. 1997 Nov 7;40(23):3773-80. | |||
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