Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0AJ1V
|
|||
| Drug Name |
Silvestrol
|
|||
| Synonyms |
Naturally derived compounds (cancer); Naturally derived compounds (cancer), Bristol-Myers Squibb/National Cancer Institute
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Middle East Respiratory Syndrome (MERS) [ICD-11: 1D64] | Investigative | [1] | |
| Therapeutic Class |
Antiviral Agents
|
|||
| Company |
Bristol-Myers Squibb Co
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C34H38O13
|
|||
| Canonical SMILES |
COC1C(OC(CO1)C(CO)O)OC2=CC3=C(C(=C2)OC)C4(C(C(C(C4(O3)C5=CC=C(C=C5)OC)C6=CC=CC=C6)C(=O)OC)O)O
|
|||
| InChI |
1S/C34H38O13/c1-40-20-12-10-19(11-13-20)34-27(18-8-6-5-7-9-18)26(30(38)42-3)29(37)33(34,39)28-23(41-2)14-21(15-24(28)47-34)45-32-31(43-4)44-17-25(46-32)22(36)16-35/h5-15,22,25-27,29,31-32,35-37,39H,16-17H2,1-4H3/t22-,25-,26-,27-,29-,31-,32-,33+,34+/m1/s1
|
|||
| InChIKey |
GVKXFVCXBFGBCD-QKDMMWSPSA-N
|
|||
| CAS Number |
CAS 697235-38-4
|
|||
| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:66484
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | HUMAN eukaryotic initiation factor-4A (eIF4A) | Target Info | Inhibitor | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona- and picornaviruses. Antiviral Res. 2018 Feb;150:123-129. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.