Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0AB4Q
|
|||
| Former ID |
DCL000551
|
|||
| Drug Name |
Ispronicline
|
|||
| Synonyms |
RJR 1734; TC 01734; AZD-3480; RJR-1734; Ispronicline (INN/USAN); (E)-N-methyl-5-(5-propan-2-yloxypyridin-3-yl)pent-4-en-2-amine
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9] | Discontinued in Phase 2 | [1] | |
| Schizophrenia [ICD-11: 6A20] | Discontinued in Phase 2 | [1] | ||
| Company |
AstraZeneca
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C14H22N2O
|
|||
| Canonical SMILES |
CC(C)OC1=CN=CC(=C1)C=CCC(C)NC
|
|||
| InChI |
1S/C14H22N2O/c1-11(2)17-14-8-13(9-16-10-14)7-5-6-12(3)15-4/h5,7-12,15H,6H2,1-4H3/b7-5+/t12-/m0/s1
|
|||
| InChIKey |
RPCVIAXDAUMJJP-PZBABLGHSA-N
|
|||
| CAS Number |
CAS 252870-53-4
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011083) | |||
| REF 2 | Ispronicline: a novel alpha4beta2 nicotinic acetylcholine receptor-selective agonist with cognition-enhancing and neuroprotective properties. J Mol Neurosci. 2006;30(1-2):19-20. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.