Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0A9SA
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| Former ID |
DNCL002792
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| Drug Name |
Canfosfamide
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| Synonyms |
Telcyta (TN)
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 3 | [1] | |
| Company |
Telik
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| Structure |
 |
Download2D MOL
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| Formula |
C26H40Cl4N5O10PS
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| Canonical SMILES |
C1=CC=C(C=C1)C(C(=O)O)NC(=O)C(CS(=O)(=O)CCOP(=O)(N(CCCl)CCCl)N(CCCl)CCCl)NC(=O)CCC(C(=O)O)N
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| InChI |
1S/C26H40Cl4N5O10PS/c27-8-12-34(13-9-28)46(42,35(14-10-29)15-11-30)45-16-17-47(43,44)18-21(32-22(36)7-6-20(31)25(38)39)24(37)33-23(26(40)41)19-4-2-1-3-5-19/h1-5,20-21,23H,6-18,31H2,(H,32,36)(H,33,37)(H,38,39)(H,40,41)/t20-,21-,23+/m0/s1
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| InChIKey |
OJLHWPALWODJPQ-QNWVGRARSA-N
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| CAS Number |
CAS 158382-37-7
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:135883
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glutathione S-transferase P (GSTP1) | Target Info | Modulator | [1], [2] |
| BioCyc | Glutathione-mediated detoxification | |||
| 4-hydroxy-2-nonenal detoxification | ||||
| KEGG Pathway | Glutathione metabolism | |||
| Metabolism of xenobiotics by cytochrome P450 | ||||
| Drug metabolism - cytochrome P450 | ||||
| Pathways in cancer | ||||
| Chemical carcinogenesis | ||||
| Prostate cancer | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Mechanism of glutathione transferase P1-1-catalyzed activation of the prodrug canfosfamide (TLK286, TELCYTA). Biochemistry. 2013 Nov 12;52(45):8069-78. | |||
| REF 2 | Phase 1 study of TLK286 (Telcyta) administered weekly in advanced malignancies. Clin Cancer Res. 2004 Jun 1;10(11):3689-98. | |||
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