Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0A9CK
|
|||
| Former ID |
DNC001259
|
|||
| Drug Name |
S-4048
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2], [3], [4] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C32H30ClN3O7
|
|||
| Canonical SMILES |
C1C(C1C2=CC=C(C=C2)Cl)COC3(CC(C(C(C3)OC(=O)C=C(C4=CC=CC=C4)N5C=NC6=C5C=CC=N6)O)O)C(=O)O
|
|||
| InChI |
1S/C32H30ClN3O7/c33-22-10-8-19(9-11-22)23-13-21(23)17-42-32(31(40)41)15-26(37)29(39)27(16-32)43-28(38)14-25(20-5-2-1-3-6-20)36-18-35-30-24(36)7-4-12-34-30/h1-12,14,18,21,23,26-27,29,37,39H,13,15-17H2,(H,40,41)/b25-14-/t21-,23+,26+,27+,29+,32-/m0/s1
|
|||
| InChIKey |
MYXPHMOLFCUDIL-MLFVSVOESA-N
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glucose-6-phosphate translocase (SLC37A4) | Target Info | Inhibitor | [1], [2], [3], [4] |
| KEGG Pathway | Carbohydrate digestion and absorption | |||
| Pathwhiz Pathway | Gluconeogenesis | |||
| Mitochondrial Electron Transport Chain | ||||
| Reactome | Glucose transport | |||
| WikiPathways | Metabolism of carbohydrates | |||
| Hexose transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Glucose release from GLUT2-null hepatocytes: characterization of a major and a minor pathway. Am J Physiol Endocrinol Metab. 2002 Apr;282(4):E794-801. | |||
| REF 2 | Normal kinetics of intestinal glucose absorption in the absence of GLUT2: evidence for a transport pathway requiring glucose phosphorylation and tr... Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11330-5. | |||
| REF 3 | Fatty acid and amino acid modulation of glucose cycling in isolated rat hepatocytes. Biochem J. 2001 Sep 15;358(Pt 3):665-71. | |||
| REF 4 | Alterations of carbohydrate and lipid intermediary metabolism during inhibition of glucose-6-phosphatase in rats. Eur J Pharmacol. 1999 Dec 10;386(1):75-82. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.