Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D0A1LS
|
|||
Former ID |
DIB012915
|
|||
Drug Name |
Genz-644282
|
|||
Synonyms |
Genz-644283; Anticancer compound (cancer), Genzyme
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [1] | |
Company |
Genzyme Corp
|
|||
Structure |
Download2D MOL |
|||
Formula |
C22H21N3O5
|
|||
Canonical SMILES |
CNCCN1C2=C(C=NC3=CC4=C(C=C32)OCO4)C5=CC(=C(C=C5C1=O)OC)OC
|
|||
InChI |
1S/C22H21N3O5/c1-23-4-5-25-21-14-8-19-20(30-11-29-19)9-16(14)24-10-15(21)12-6-17(27-2)18(28-3)7-13(12)22(25)26/h6-10,23H,4-5,11H2,1-3H3
|
|||
InChIKey |
BAORCAMWLWRZQG-UHFFFAOYSA-N
|
|||
CAS Number |
CAS 529488-28-6
|
|||
PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | DNA topoisomerase I (TOP1) | Target Info | Inhibitor | [2] |
NetPath Pathway | IL2 Signaling Pathway | |||
Panther Pathway | DNA replication | |||
Pathway Interaction Database | Caspase Cascade in Apoptosis | |||
WikiPathways | Integrated Pancreatic Cancer Pathway |
References | Top | |||
---|---|---|---|---|
REF 1 | ClinicalTrials.gov (NCT00942799) Dose Escalation Study to Assess the Safety and Tolerability of Genz-644282 in Patients With Solid Tumors. U.S. National Institutes of Health. | |||
REF 2 | Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment. Clin Cancer Res. 2011 May 1;17(9):2777-87. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.