Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0A1IL
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| Former ID |
DNCL002497
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| Drug Name |
VAL-083
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| Synonyms |
VAL-083; Dianhydrogalactitol; 23261-20-3; UNII-4S465RYF7M; 1,2:5,6-DIANHYDROGALACTITOL; Dulcitoldiepoxide; 4S465RYF7M; Dianhydrogalactitol [USAN:INN]; SCHEMBL4306431; Dianhydrogalactitol (USAN/INN); CHEMBL3137322; AAFJXZWCNVJTMK-GUCUJZIJSA-N; ZINC4963497; CS-1358; DB12873; NSC-1323313; HY-16513; BC657197; D10623; W-5268; J-015059; 457899-38-6
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| Drug Type |
Small molecular drug
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| Indication | Recurrent glioblastoma [ICD-11: 2A00.00; ICD-10: C71] | Phase 3 | [1] | |
| Recurring respiratory infection [ICD-11: CA07-CA45; ICD-10: J01.81] | Phase 3 | [2] | ||
| Acute myeloid leukaemia [ICD-11: 2A60] | Phase 1/2 | [3] | ||
| Grade IV malignant glioma [ICD-11: 2A00.0] | Phase 1/2 | [3] | ||
| Company |
Del Mar Pharmaceuticals
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| Structure |
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Download2D MOL |
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| Formula |
C6H10O4
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| Canonical SMILES |
C1C(O1)C(C(C2CO2)O)O
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| InChI |
1S/C6H10O4/c7-5(3-1-9-3)6(8)4-2-10-4/h3-8H,1-2H2/t3-,4+,5+,6-
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| InChIKey |
AAFJXZWCNVJTMK-GUCUJZIJSA-N
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| CAS Number |
CAS 23261-20-3
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human Deoxyribonucleic acid (hDNA) | Target Info | Modulator | [4] |
| References | Top | |||
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| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 3 | ClinicalTrials.gov (NCT01478178) Safety Study of VAL-083 in Patients With Recurrent Malignant Glioma. U.S. National Institutes of Health. | |||
| REF 4 | Effect of 1,2:5,6-dianhydrogalactitol and 1,2:5,6-dianhydro-3,4-diacetylgalactitol on DNA synthesis in the cells of melanoma B16, bone marrow, small intestine epithelium, spleen and liver of mice. Biull Eksp Biol Med. 1984 Sep;98(9):301-3. | |||
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