Drug Information
Drug General Information | Top | |||
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Drug ID |
D0A0BK
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Former ID |
DIB014318
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Drug Name |
Cal-1
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Synonyms |
Cal-1-transduced hematopoietic
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Indication | Human immunodeficiency virus-1 infection [ICD-11: 1C62; ICD-10: B20-B24] | Phase 1/2 | [1] | |
Company |
Calimmune
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Target and Pathway | Top | |||
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Target(s) | C-C chemokine receptor type 5 (CCR5) | Target Info | Modulator | [2] |
KEGG Pathway | Cytokine-cytokine receptor interaction | |||
Chemokine signaling pathway | ||||
Endocytosis | ||||
Toxoplasmosis | ||||
Viral carcinogenesis | ||||
NetPath Pathway | TSLP Signaling Pathway | |||
TCR Signaling Pathway | ||||
IL2 Signaling Pathway | ||||
Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
Pathway Interaction Database | IL12-mediated signaling events | |||
Reactome | Binding and entry of HIV virion | |||
Chemokine receptors bind chemokines | ||||
G alpha (i) signalling events | ||||
WikiPathways | TCR Signaling Pathway | |||
GPCRs, Class A Rhodopsin-like | ||||
HIV Life Cycle | ||||
Peptide GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT01734850) Safety Study of a Dual Anti-HIV Gene Transfer Construct to Treat HIV-1 Infection. U.S. National Institutes of Health. | |||
REF 2 | Preclinical safety and efficacy of an anti-HIV-1 lentiviral vector containing a short hairpin RNA to CCR5 and the C46 fusion inhibitor. Mol Ther Methods Clin Dev. 2014 Feb 12;1:11. |
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