Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09YDM
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| Former ID |
DNC000385
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| Drug Name |
Camptothecin
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| Synonyms |
camptothecin; Camptothecine; 7689-03-4; (S)-(+)-Camptothecin; Campathecin; d-Camptothecin; (+)-Camptothecine; (+)-Camptothecin; 20(S)-Camptothecine; 21,22-Secocamptothecin-21-oic acid lactone; NSC94600; (S)-Camptothecin; Camptothecine (8CI); 20(S)-Camptothecin; Camptothecine (S,+); CHEMBL65; UNII-XT3Z54Z28A; MLS000766223; (4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; XT3Z54Z28A; CHEBI:27656; VSJKWCGYPAHWDS-FQEVSTJZSA-N; Camptothecin, Camptotheca acuminata; NSC-94600; Camptothecin derivat
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 3 | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C20H16N2O4
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| Canonical SMILES |
CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O
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| InChI |
1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
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| InChIKey |
VSJKWCGYPAHWDS-FQEVSTJZSA-N
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| CAS Number |
CAS 7689-03-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5009, 399733, 597746, 842008, 925175, 3140967, 7887296, 7978848, 8139651, 8150064, 8167780, 10321203, 11111011, 11112910, 11113913, 11120280, 11120768, 11121256, 11336001, 11341983, 11361240, 11362166, 11363193, 11365755, 11368317, 11372185, 11374175, 11376479, 11377982, 11446457, 11462212, 11466228, 11467348, 11484482, 11485816, 11487568, 11488719, 11491018, 11492553, 11494113, 11537709, 14827597, 14900711, 17404904, 24278352, 26612343, 26680346, 26732559, 26747153, 26747154
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| ChEBI ID |
CHEBI:27656
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| Drug Resistance Mutation (DRM) | Top | |||
|---|---|---|---|---|
| DRM | DRM Info | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA topoisomerase I (TOP1) | Target Info | Modulator | [1], [2] |
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | DNA replication | |||
| Pathway Interaction Database | Caspase Cascade in Apoptosis | |||
| WikiPathways | Integrated Pancreatic Cancer Pathway | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer. 2006 Oct;6(10):789-802. | |||
| REF 2 | Mechanism of action of camptothecin.Ann N Y Acad Sci.2000;922:1-10. | |||
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