Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09XQU
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| Former ID |
DIB016952
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| Drug Name |
Tirapazamine
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| Synonyms |
TPZ; Tirazone; SR-259075; SR-4233; SR-4317; SR-4330; SR-4482; Win-59075
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| Drug Type |
Small molecular drug
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| Indication | Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9; ICD-9: 331] | Phase 3 | [1] | |
| Hepatocellular carcinoma [ICD-11: 2C12.02; ICD-10: C22.0; ICD-9: 155] | Phase 2 | [2] | ||
| Company |
Sri international
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| Structure |
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Download2D MOL |
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| Formula |
C7H6N4O2
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| Canonical SMILES |
C1=CC=C2C(=C1)[N+](=C(N=[N+]2[O-])N)[O-]
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| InChI |
1S/C7H6N4O2/c8-7-9-11(13)6-4-2-1-3-5(6)10(7)12/h1-4H,(H2,8,9)
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| InChIKey |
ORYDPOVDJJZGHQ-UHFFFAOYSA-N
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| CAS Number |
CAS 27314-97-2
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:78887
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA topoisomerase II (TOP2) | Target Info | Modulator | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00262821) Cisplatin and Radiation Therapy With or Without Tirapazamine in Treating Patients With Cervical Cancer. U.S. National Institutes of Health. | |||
| REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 3 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | |||
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