Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09VXM
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| Former ID |
DNAP001270
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| Drug Name |
Crofelemer
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| Synonyms |
Fulyzaq (TN)
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| Drug Type |
Small molecular drug
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| Indication | HIV-associated diarrhoea [ICD-11: 1A2Z; ICD-10: A08.3, A08.4] | Approved | [1], [2], [3] | |
| Company |
Salix
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| Structure |
 |
Download2D MOL |
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| Formula |
C18H16N2O3
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| Canonical SMILES |
COC1=CC=CC=C1CNC(=O)C2=NOC(=C2)C3=CC=CC=C3
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| InChI |
1S/C18H16N2O3/c1-22-16-10-6-5-9-14(16)12-19-18(21)15-11-17(23-20-15)13-7-3-2-4-8-13/h2-11H,12H2,1H3,(H,19,21)
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| InChIKey |
JDNAIBCYTQGWFC-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ADReCS Drug ID | BADD_D00536 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Calcium-dependent chloride channel anoctamin (ANO) | Target Info | Modulator | [2], [3] |
| cAMP-dependent chloride channel (CFTR) | Target Info | Modulator | [2], [3] | |
| KEGG Pathway | ABC transporters | |||
| cAMP signaling pathway | ||||
| AMPK signaling pathway | ||||
| Gastric acid secretion | ||||
| Pancreatic secretion | ||||
| Bile secretion | ||||
| Vibrio cholerae infection | ||||
| Reactome | Stimuli-sensing channels | |||
| ABC-family proteins mediated transport | ||||
| WikiPathways | ABC-family proteins mediated transport | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7453). | |||
| REF 2 | Nat Rev Drug Discov. 2013 Feb;12(2):87-90. | |||
| REF 3 | Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels. Mol Pharmacol. 2010 Jan;77(1):69-78. | |||
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