Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09VTB
|
|||
| Former ID |
DIB010538
|
|||
| Drug Name |
IDX-320
|
|||
| Synonyms |
Hepatitis C virus NS3/4A protease inhibitor (oral/tablet formulation), Idenix Pharmaceuticals; Hepatitis C virus replication inhibitor (oral/tablet formulation, HCV infection), Idenix Pharmaceuticals
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Hepatitis C virus infection [ICD-11: 1E51.1; ICD-10: B18.2] | Discontinued in Phase 1/2 | [1] | |
| Company |
Idenix Pharmaceuticals Inc
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C37H43F3N6O7S2
|
|||
| Canonical SMILES |
CC1=C(C=CC2=C1N=C(C=C2OC3CCN4C(C3)C(=O)NC5(CC5C=CCCCCN(C4=O)C)C(=O)NS(=O)(=O)C6(CC6)C)C7=NC(=CS7)C(F)(F)F)OC
|
|||
| InChI |
1S/C37H43F3N6O7S2/c1-21-27(52-4)11-10-24-28(18-25(41-30(21)24)32-42-29(20-54-32)37(38,39)40)53-23-12-16-46-26(17-23)31(47)43-36(33(48)44-55(50,51)35(2)13-14-35)19-22(36)9-7-5-6-8-15-45(3)34(46)49/h7,9-11,18,20,22-23,26H,5-6,8,12-17,19H2,1-4H3,(H,43,47)(H,44,48)/b9-7+/t22-,23+,26+,36-/m1/s1
|
|||
| InChIKey |
YEPBUHWNLNKZBW-FDVAVYTKSA-N
|
|||
| CAS Number |
CAS 1251165-81-7
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Hepatitis C virus Serine protease NS4A (HCV NS4A) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031987) | |||
| REF 2 | Rapid decline of viral RNA in chronic hepatitis C patients treated once daily with IDX320: a novel macrocyclic HCV protease inhibitor.Antivir Ther.2012;17(4):633-42. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.