Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D09VBC
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| Former ID |
DIB000965
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| Drug Name |
Carbetapentane
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| Synonyms |
Carbetapentane citrate; Pentoxyverine citrate; 23142-01-0; Loucarbate; Pentoxiverine citrate; Carbetapentane citrate salt; Toclase; Toclase citrate; Carbetapentone citrate; Carbetapentane (citrate); UNII-4SH0MFJ5HJ; Carbetapentane citrate [NF]; EINECS 245-449-5; 4SH0MFJ5HJ; 2-(2-diethylaminoethoxy)ethyl 1-phenylcyclopentanecarboxylate citrate; 2-(2(Diethylamino)ethoxy)ethyl 1-phenyl-cyclopentanecarboxylate citrate (1:1); 2-(2-(Diethylamino)ethoxy)ethyl 1-phenylcyclopentyl-1-carboxylate dihydrogen citrate; Ethanol, 2-(2-(die
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| Drug Type |
Small molecular drug
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| Indication | Cough [ICD-11: MD12; ICD-10: R05; ICD-9: 786.2] | Approved | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C20H31NO3
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| Canonical SMILES |
CCN(CC)CCOCCOC(=O)C1(CCCC1)C2=CC=CC=C2
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| InChI |
1S/C20H31NO3/c1-3-21(4-2)14-15-23-16-17-24-19(22)20(12-8-9-13-20)18-10-6-5-7-11-18/h5-7,10-11H,3-4,8-9,12-17H2,1-2H3
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| InChIKey |
CFJMRBQWBDQYMK-UHFFFAOYSA-N
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| CAS Number |
CAS 77-23-6
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:94484
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides dorei DSM 17855
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carbetapentane citrate can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -0.344; p = 0.031). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carbetapentane citrate can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -0.43; p = 0.023). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carbetapentane citrate can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -0.335; p = 0.041). | |||
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Studied Microbe: Odoribacter splanchnicus
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|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carbetapentane citrate can be metabolized by Odoribacter splanchnicus (log2FC = -0.342; p = 0.008). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia hansenii DSM20583
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|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carbetapentane citrate can be metabolized by Blautia hansenii DSM20583 (log2FC = -0.451; p = 0.008). | |||
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Studied Microbe: Clostridium sp.
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|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carbetapentane citrate can be metabolized by Clostridium sp. (log2FC = -0.444; p = 0.027). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Victivallales | ||||
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Studied Microbe: Victivallis vadensis ATCC BAA-548
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|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carbetapentane citrate can be metabolized by Victivallis vadensis ATCC BAA-548 (log2FC = -1.649; p = 0.01). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
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