Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D09UXE
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| Former ID |
DAP001384
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| Drug Name |
Fosmidomycin
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| Synonyms |
FOM; Fosmidomycina; Fosmidomycine; Fosmidomycinum; FR-31564; Fosmidomycina [INN-Spanish]; Fosmidomycine [INN-French]; Fosmidomycinum [INN-Latin]; {3-[formyl(hydroxy)amino]propyl}phosphonic acid; (3-(Formylhydroxyamino)propyl)phosphonic acid, monosodium salt; (3-(N-Hydroxyformamido)propyl)phosphonic acid; 3-(Formyl-hydroxy-amino)propylphosphonic acid; 3-(N-Formyl-N-hydroxyamino)-propylphosphonic acid; 3-(N-hydroxyformamido)propylphosphonic acid; 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID
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| Drug Type |
Small molecular drug
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| Indication | Malaria [ICD-11: 1F40-1F45; ICD-10: B50-B64, B54] | Approved | [1] | |
| Therapeutic Class |
Antimalarials
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| Structure |
 |
Download2D MOL |
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| Formula |
C4H10NO5P
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| Canonical SMILES |
C(CN(C=O)O)CP(=O)(O)O
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| InChI |
1S/C4H10NO5P/c6-4-5(7)2-1-3-11(8,9)10/h4,7H,1-3H2,(H2,8,9,10)
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| InChIKey |
GJXWDTUCERCKIX-UHFFFAOYSA-N
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| CAS Number |
CAS 66508-53-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
635741, 829974, 829978, 6824013, 7887540, 8150695, 12013045, 14772783, 24438937, 24770449, 24770452, 24775892, 46508936, 57320307, 77091619, 85189537, 87351364, 103484386, 104041488, 104295219, 124767433, 125299568, 127964616, 132554641, 134338592, 134356981, 135026291, 135383608, 137005415, 139973951, 140587175, 152137930, 160966106, 163056304, 174006643, 179148058, 183813920, 183813925, 198962774, 223726031, 223865850, 226642142, 241117412, 252543205
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| ChEBI ID |
CHEBI:443725
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Plasmodium DOXP reductoisomerase (Malaria DXR) | Target Info | Binder | [2], [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71. | |||
| REF 2 | Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the cata... J Biol Chem. 2003 May 16;278(20):18401-7. | |||
| REF 3 | The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51. | |||
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