Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D09SFJ
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| Former ID |
DIB018874
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| Drug Name |
AR-C126313
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| Synonyms |
compound 71a [PMID: 15078212]; compound 52 [PMID: 18600475]
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C17H12ClN3OS2
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| Canonical SMILES |
CN1C=C(C(=S)NC1=O)C2C3=C(C=CC4=C2N=CS4)C=C(C=C3)Cl
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| InChI |
1S/C17H12ClN3OS2/c1-21-7-12(16(23)20-17(21)22)14-11-4-3-10(18)6-9(11)2-5-13-15(14)19-8-24-13/h2-8,14H,1H3,(H,20,22,23)
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| InChIKey |
ZDHQVQVNOIWLNX-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | P2Y purinoceptor 2 (P2RY2) | Target Info | Antagonist | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Inflammatory mediator regulation of TRP channels | ||||
| NetPath Pathway | IL5 Signaling Pathway | |||
| Reactome | G alpha (q) signalling events | |||
| P2Y receptors | ||||
| Surfactant metabolism | ||||
| WikiPathways | Nucleotide GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Molecular recognition at purine and pyrimidine nucleotide (P2) receptors. Curr Top Med Chem. 2004;4(8):805-19. | |||
| REF 2 | Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate. J Med Chem. 2007 Mar 22;50(6):1166-76. | |||
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