Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09OWK
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| Former ID |
DIB002896
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| Drug Name |
AGN-2979
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| Synonyms |
BTG-1501; SC-48274; AGN-2979 (free base); 3-[3-(Dimethylamino)propyl]-3-(3-methoxyphenyl)-4,4-dimethylpiperidine-2,6-dione; 3-[3-(Dimethylamino)propyl]-3-(3-methoxyphenyl)-4,4-dimethylpiperidine-2,6-dione monohydrochloride
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| Drug Type |
Small molecular drug
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| Indication | Psychotic disorder [ICD-11: 6A20-6A25] | Phase 2 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C19H28N2O3
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| Canonical SMILES |
CC1(CC(=O)NC(=O)C1(CCCN(C)C)C2=CC(=CC=C2)OC)C
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| InChI |
1S/C19H28N2O3/c1-18(2)13-16(22)20-17(23)19(18,10-7-11-21(3)4)14-8-6-9-15(12-14)24-5/h6,8-9,12H,7,10-11,13H2,1-5H3,(H,20,22,23)
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| InChIKey |
UJFNSGBGJMRZKS-UHFFFAOYSA-N
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| CAS Number |
CAS 53873-21-5
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tryptophan 5-hydroxylase 1 (TPH1) | Target Info | Modulator | [1] |
| BioCyc | Superpathway of tryptophan utilization | |||
| Serotonin and melatonin biosynthesis | ||||
| KEGG Pathway | Tryptophan metabolism | |||
| Metabolic pathways | ||||
| Serotonergic synapse | ||||
| Panther Pathway | 5-Hydroxytryptamine biosynthesis | |||
| Pathwhiz Pathway | Tryptophan Metabolism | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Biogenic Amine Synthesis | ||||
| Tryptophan metabolism | ||||
| Metabolism of amino acids and derivatives | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats. Eur Neuropsychopharmacol. 2001 Oct;11(5):351-7. | |||
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