Drug General Information
Drug ID
D09NTG
Former ID
DNC003471
Drug Name
Taurocholic Acid
Synonyms
Taurocholic acid; TAUROCHOLIC ACID; Taurocholate; Cholyltaurine; Cholaic acid; N-Choloyltaurine; Cholic acid taurine conjugate; 81-24-3; Taurine, N-choloyl-; Acidum cholatauricum; Taurine Cholate; UNII-5E090O0G3Z; HSDB 832; C26H45NO7S; 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid 24-taurine; NSC25505; EINECS 201-336-2; NSC 25505; Ethanesulfonic acid, 2-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)-; 2-((3-alpha,7-alpha,12-alpha-Trihydroxy-24-oxo-5-be ta-cholan-24-yl)amino)ethanesulfonic acid; [3H]taurocholic acid
Drug Type
Small molecular drug
Indication Type-2 diabetes [ICD-11: 5A11; ICD-9: 250] Phase 1/2 [1]
Discovery agent [ICD-11: N.A.] Investigative [2]
Structure
Download
2D MOL

3D MOL

Formula
C26H45NO7S
InChI
1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1
InChIKey
WBWWGRHZICKQGZ-HZAMXZRMSA-N
CAS Number
CAS 81-24-3
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Bile-salt-activated lipase (CEL) Target Info Inhibitor [3]
Ileal sodium/bile acid cotransporter (SLC10A2) Target Info Modulator [4]
BioCyc Triacylglycerol degradation
KEGG Pathway Bile secretion
Reactome Recycling of bile acids and salts
WikiPathways Bile acid and bile salt metabolism
References
REF 1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4547).
REF 2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4546).
REF 3 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
REF 4 Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am J Physiol. 1998 Jan;274(1 Pt 1):G157-69.

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