Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09MIN
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| Drug Name |
LCL161
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| Indication | Multiple myeloma [ICD-11: 2A83; ICD-10: C90.0] | Phase 2 | [1] | |
| Myelofibrosis [ICD-11: 2A20.2; ICD-10: D47.4] | Phase 2 | [1] | ||
| Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Phase 2 | [2], [3], [4] | ||
| Breast cancer [ICD-11: 2C60-2C65] | Phase 1 | [1] | ||
| Company |
Novartis
|
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| Structure |
 |
Download2D MOL
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| Formula |
C26H33FN4O3S
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| Canonical SMILES |
CC(C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C3=NC(=CS3)C(=O)C4=CC=C(C=C4)F)NC
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| InChI |
1S/C26H33FN4O3S/c1-16(28-2)24(33)30-22(17-7-4-3-5-8-17)26(34)31-14-6-9-21(31)25-29-20(15-35-25)23(32)18-10-12-19(27)13-11-18/h10-13,15-17,21-22,28H,3-9,14H2,1-2H3,(H,30,33)/t16-,21-,22-/m0/s1
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| InChIKey |
UFPFGVNKHCLJJO-SSKFGXFMSA-N
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| CAS Number |
CAS 1005342-46-0
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Inhibitor of apoptosis protein (hIAP) | Target Info | Modulator | [5] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7912). | |||
| REF 3 | ClinicalTrials.gov (NCT02098161) Phase 2 LCL-161 in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (Post-PV MF) or Post-Essential Thrombocytosis Myelofibrosis (Post-ET MF). U.S. National Institutes of Health. | |||
| REF 4 | Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.Nat Rev Drug Discov. 2016 Aug;15(8):533-50. | |||
| REF 5 | National Cancer Institute Drug Dictionary (drug id 670651). | |||
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