Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09LZA
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| Former ID |
DNCL003440
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| Drug Name |
CS-4771
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| Indication | Sepsis [ICD-11: 1G40-1G41; ICD-9: 995.91] | Discontinued in Phase 1 | [1] | |
| Company |
Daiichi Sankyo
|
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| Structure |
 |
Download2D MOL |
||
| Formula |
C7H15NO3
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| Canonical SMILES |
C[N+](C)(C)CC(CC(=O)[O-])O
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| InChI |
1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3
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| InChIKey |
PHIQHXFUZVPYII-UHFFFAOYSA-N
|
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| CAS Number |
CAS 406-76-8
|
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:17126
|
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Gut microbiota unspecific | [2] | |||
| Microbial Enzyme | Carnitine oxygenase | |||
| Metabolic Reaction | Oxidation/Reduction | |||
| Resulting Metabolite | Trimethylamine | |||
| Description | Carnitine can be metabolized to Trimethylamine by the carnitine oxygenase of gut microbiota through oxidation/Reduction. | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032166) | |||
| REF 2 | Gut Reactions: Breaking Down Xenobiotic-Microbiome Interactions. Pharmacol Rev. 2019 Apr;71(2):198-224. | |||
| REF 3 | Eritoran insight for influenza treatment. SciBX 6(19); doi:10.1038/scibx.2013.453. May 16 2013 | |||
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