Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09LPI
|
|||
| Former ID |
DCL000129
|
|||
| Drug Name |
BCG65-E7
|
|||
| Indication | Anal intraepithelial neoplasia [ICD-11: 2E92.5; ICD-10: D12, D12.9] | Discontinued in Phase 3 | [1] | |
| Human papillomavirus infection [ICD-11: 1A9Y] | Discontinued in Phase 3 | [1] | ||
| Company |
Nventa BioPharma
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Toll-like receptor 3 (TLR3) | Target Info | Agonist | [2], [3] |
| KEGG Pathway | Toll-like receptor signaling pathway | |||
| Hepatitis C | ||||
| Hepatitis B | ||||
| Influenza A | ||||
| Herpes simplex infection | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | Toll receptor signaling pathway | |||
| Pathway Interaction Database | Endogenous TLR signaling | |||
| Reactome | Ligand-dependent caspase activation | |||
| MyD88-independent TLR3/TLR4 cascade | ||||
| Trafficking and processing of endosomal TLR | ||||
| RIP-mediated NFkB activation via ZBP1 | ||||
| TRIF-mediated programmed cell death | ||||
| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | ||||
| IKK complex recruitment mediated by RIP1 | ||||
| TRAF6 mediated induction of TAK1 complex | ||||
| WikiPathways | Toll-like receptor signaling pathway | |||
| Cytosolic sensors of pathogen-associated DNA | ||||
| Toll-Like Receptors Cascades | ||||
| MyD88-independent cascade | ||||
| Trafficking and processing of endosomal TLR | ||||
| Regulation of toll-like receptor signaling pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009576) | |||
| REF 2 | Serological response to an HPV16 E7 based therapeutic vaccine in women with high-grade cervical dysplasia. Gynecol Oncol. 2010 Feb;116(2):208-12. | |||
| REF 3 | Medical treatment of cervical intraepithelial neoplasia II, III: an update review. Int J Clin Oncol. 2009 Feb;14(1):37-42. | |||
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