Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09JHT
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| Former ID |
DIB020829
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| Drug Name |
Ro26-4550
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| Synonyms |
Ro-26-4550
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C26H30N4O3
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| Canonical SMILES |
COC(=O)C(CC1=CC=C(C=C1)C#CC2=CC=CC=C2)NC(=O)CC3CCCN(C3)C=NN
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| InChI |
1S/C26H30N4O3/c1-33-26(32)24(29-25(31)17-23-8-5-15-30(18-23)19-28-27)16-22-13-11-21(12-14-22)10-9-20-6-3-2-4-7-20/h2-4,6-7,11-14,19,23-24H,5,8,15-18,27H2,1H3,(H,29,31)/t23-,24+/m1/s1
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| InChIKey |
YQDXLNDLKSCQKX-RPWUZVMVSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Interleukin 2 receptor (IL2R) | Target Info | Antagonist | [2] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Endocytosis | ||||
| PI3K-Akt signaling pathway | ||||
| Jak-STAT signaling pathway | ||||
| Hematopoietic cell lineage | ||||
| Measles | ||||
| HTLV-I infection | ||||
| Reactome | GPVI-mediated activation cascade | |||
| Interleukin-7 signaling | ||||
| G beta:gamma signalling through PI3Kgamma | ||||
| Interleukin-2 signaling | ||||
| RAF/MAP kinase cascade | ||||
| Interleukin receptor SHC signaling | ||||
| WikiPathways | IL-2 Signaling Pathway | |||
| Inflammatory Response Pathway | ||||
| Interleukin-2 signaling | ||||
| Allograft Rejection | ||||
| TSLP Signaling Pathway | ||||
| IL-7 Signaling Pathway | ||||
| Interleukin-3, 5 and GM-CSF signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5052). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2297). | |||
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