Drug Information
Drug General Information | Top | |||
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Drug ID |
D09IQG
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Former ID |
DIB019570
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Drug Name |
PMID7966163C6g
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Synonyms |
GTPL3118; BDBM50038087
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
Structure |
Download2D MOL
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Formula |
C42H56O14
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Canonical SMILES |
CC(CC1=CC=CC=C1)C(C(=C)CCC23C(C(C(O2)(C(C(O3)C(=O)O)(C(=O)O)O)C(=O)O)OCCCCCCCCCCCOC4=CC=CC=C4)O)OC(=O)C
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InChI |
1S/C42H56O14/c1-28(33(54-30(3)43)29(2)27-31-19-13-11-14-20-31)23-24-40-34(44)35(42(56-40,39(49)50)41(51,38(47)48)36(55-40)37(45)46)53-26-18-10-8-6-4-5-7-9-17-25-52-32-21-15-12-16-22-32/h11-16,19-22,29,33-36,44,51H,1,4-10,17-18,23-27H2,2-3H3,(H,45,46)(H,47,48)(H,49,50)/t29-,33-,34-,35-,36?,40?,41?,42?/m1/s1
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InChIKey |
QBTROWHSMGZXCV-RQURQNPSSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Squalene synthetase (FDFT1) | Target Info | Inhibitor | [1] |
BioCyc | Cholesterol biosynthesis II (via 24,25-dihydrolanosterol) | |||
Cholesterol biosynthesis III (via desmosterol) | ||||
Cholesterol biosynthesis I | ||||
Superpathway of cholesterol biosynthesis | ||||
Epoxysqualene biosynthesis | ||||
KEGG Pathway | Steroid biosynthesis | |||
Metabolic pathways | ||||
Biosynthesis of antibiotics | ||||
Panther Pathway | Cholesterol biosynthesis | |||
Pathwhiz Pathway | Steroid Biosynthesis | |||
Reactome | Cholesterol biosynthesis | |||
PPARA activates gene expression | ||||
Activation of gene expression by SREBF (SREBP) | ||||
WikiPathways | Statin Pathway | |||
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||||
Activation of Gene Expression by SREBP (SREBF) | ||||
SREBP signalling | ||||
Cholesterol Biosynthesis | ||||
Cholesterol biosynthesis |
References | Top | |||
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REF 1 | Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives. J Med Chem. 1994 Nov 11;37(23):4031-51. | |||
REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3118). |
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