Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09HTB
|
|||
| Former ID |
DCL000635
|
|||
| Drug Name |
SAR153191
|
|||
| Indication | Ankylosing spondylitis [ICD-11: FA92.0; ICD-10: M45; ICD-9: 720] | Phase 3 | [1], [2] | |
| Company |
Sanofi-Aventis
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Interleukin 6 receptor (IL6R) | Target Info | Antagonist | [3] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| HIF-1 signaling pathway | ||||
| PI3K-Akt signaling pathway | ||||
| Jak-STAT signaling pathway | ||||
| Hematopoietic cell lineage | ||||
| Non-alcoholic fatty liver disease (NAFLD) | ||||
| Reactome | MAPK3 (ERK1) activation | |||
| MAPK1 (ERK2) activation | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Senescence and Autophagy in Cancer | ||||
| IL-6 signaling pathway | ||||
| Differentiation Pathway | ||||
| Interleukin-6 signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7999). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027858) | |||
| REF 3 | Pharma & Vaccines. Product Development Pipeline. April 29 2009. | |||
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