Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09HFJ
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| Former ID |
DIB005383
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| Drug Name |
NM-3
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| Synonyms |
NM-3; 181427-78-1; isocoumarin NM-3; NM 3 (isocoumarin); NM 3; NM-3 (isocoumarin); AC1NUU2Q; SCHEMBL3191297; CTK4D7870; 2-(8-Hydroxy-6-methoxy-1-oxo-1H-isochromen-3-yl)propionic acid; 8-Hydroxy-6-methoxy-alpha-methyl-1-oxo-1H-2-benzopyran-3-acetic acid; AKOS030619018; DB12818; FT-0717128; 2-(8-hydroxy-6-methoxy-1-oxoisochromen-3-yl)propanoic acid; 2-(8-hydroxy-6-methoxy-1-oxo-1h-2-benzopyran-3-yl) propionic acid; 2-(8-hydroxy-6-methoxy-1-oxo-1H-isochromen-3-yl)propanoic acid; 1H-2-Benzopyran-3-aceticacid, 8-hydroxy-6-methox
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Phase 1 | [1] | |
| Company |
Genzyme
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| Structure |
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Download2D MOL |
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| Formula |
C13H12O6
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| Canonical SMILES |
CC(C1=CC2=CC(=CC(=C2C(=O)O1)O)OC)C(=O)O
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| InChI |
1S/C13H12O6/c1-6(12(15)16)10-4-7-3-8(18-2)5-9(14)11(7)13(17)19-10/h3-6,14H,1-2H3,(H,15,16)
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| InChIKey |
BPZCXUROMKDLGX-UHFFFAOYSA-N
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| CAS Number |
CAS 181427-78-1
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Vascular endothelial growth factor (VEGF) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00046696) A Study of NM-3 Administered Orally in Patients With Advanced Solid Tumors.. U.S. National Institutes of Health. | |||
| REF 2 | 2-(8-hydroxy-6-methoxy-1-oxo-1h-2-benzopyran-3-yl) propionic acid, an inhibitor of angiogenesis, ameliorates renal alterations in obese type 2 diabetic mice. Diabetes. 2006 May;55(5):1232-42. | |||
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