Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08ZYC
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| Former ID |
DIB019990
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| Drug Name |
GW9508
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| Synonyms |
GW-9508; GW 9508
Click to Show/Hide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C22H21NO3
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| Canonical SMILES |
C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)CCC(=O)O
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| InChI |
1S/C22H21NO3/c24-22(25)14-11-17-9-12-19(13-10-17)23-16-18-5-4-8-21(15-18)26-20-6-2-1-3-7-20/h1-10,12-13,15,23H,11,14,16H2,(H,24,25)
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| InChIKey |
DGENZVKCTGIDRZ-UHFFFAOYSA-N
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| CAS Number |
CAS 885101-89-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
16698070, 23708414, 42762266, 49645546, 49846310, 50112950, 80421949, 85788718, 87226550, 99460886, 103484347, 121361427, 123220348, 124788103, 125335441, 134964476, 135650341, 135698715, 138642309, 160826725, 161005267, 162012040, 162023486, 162205208, 162248638, 163092951, 163387312, 163564505, 163620974, 163685841, 163686297, 163841192, 164045136, 172087030, 172650531, 175612441, 178120700, 179503240, 186021012, 196362640, 198946013, 204406063, 223377664, 223573627, 223704419, 226696985, 242059757, 247559601, 249737677, 252156682
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| ChEBI ID |
CHEBI:93259
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Free fatty acid receptor 1 (GPR40) | Target Info | Agonist | [2] |
| G-protein coupled receptor 120 (GPR120) | Target Info | Agonist | [3] | |
| KEGG Pathway | Insulin secretion | |||
| Reactome | G alpha (q) signalling events | |||
| Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | ||||
| WikiPathways | Incretin Synthesis, Secretion, and Inactivation | |||
| GPCR ligand binding | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Integration of energy metabolism | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1050). | |||
| REF 2 | Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small... Br J Pharmacol. 2006 Jul;148(5):619-28. | |||
| REF 3 | Free fatty acid receptors and drug discovery. Biol Pharm Bull. 2008 Oct;31(10):1847-51. | |||
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