Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08VLD
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| Former ID |
DNC013660
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| Drug Name |
Racemic DOTFM
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| Synonyms |
Racemic DOTFM; CHEMBL6620; 2-(2,5-Dimethoxy-4-trifluoromethyl-phenyl)-1-methyl-ethylamine; 159277-07-3; DOTFM; SCHEMBL14655679; DTXSID40439330; BDBM50038370
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C12H16F3NO2
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| Canonical SMILES |
CC(CC1=CC(=C(C=C1OC)C(F)(F)F)OC)N
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| InChI |
1S/C12H16F3NO2/c1-7(16)4-8-5-11(18-3)9(12(13,14)15)6-10(8)17-2/h5-7H,4,16H2,1-3H3
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| InChIKey |
WPGOTSORDNBMHP-UHFFFAOYSA-N
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| CAS Number |
CAS 159277-07-3
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 2A receptor (HTR2A) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Serotonergic synapse | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | 5HT2 type receptor mediated signaling pathway | |||
| Reactome | Serotonin receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Serotonin Receptor 2 and STAT3 Signaling | |||
| Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | ||||
| SIDS Susceptibility Pathways | ||||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands. Bioorg Med Chem. 2008 Apr 15;16(8):4661-9. | |||
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