Drug Information
Drug General Information | Top | |||
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Drug ID |
D08VGT
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Former ID |
DIB000950
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Drug Name |
BMY-30129
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Synonyms |
BMS-181162; 4-(3-Carboxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-2(Z),4(E),6(E),8(E)-nonatetraenoicacid
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Indication | Pruritus [ICD-11: EC90; ICD-10: L29, L29.9; ICD-9: 698] | Discontinued in Phase 2 | [1] | |
Structure |
Download2D MOL |
Target and Pathway | Top | |||
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Target(s) | Phospholipase A2 (PLA2G1B) | Target Info | Inhibitor | [2], [3] |
BioCyc | Phospholipases | |||
KEGG Pathway | Glycerophospholipid metabolism | |||
Ether lipid metabolism | ||||
Arachidonic acid metabolism | ||||
Linoleic acid metabolism | ||||
alpha-Linolenic acid metabolism | ||||
Metabolic pathways | ||||
Ras signaling pathway | ||||
Vascular smooth muscle contraction | ||||
Pancreatic secretion | ||||
Fat digestion and absorption | ||||
Pathway Interaction Database | Fc-epsilon receptor I signaling in mast cells | |||
Reactome | Acyl chain remodelling of PC | |||
Acyl chain remodelling of PE | ||||
Acyl chain remodelling of PI | ||||
WikiPathways | Glycerophospholipid biosynthesis |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005019) | |||
REF 2 | Inhibitor of phospholipase A2 blocks eicosanoid and platelet activating factor biosynthesis and has topical anti-inflammatory activity. J Pharmacol Exp Ther. 1994 Nov;271(2):852-9. | |||
REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 |
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