Drug Information
Drug General Information | Top | |||
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Drug ID |
D08UWO
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Former ID |
DIB020804
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Drug Name |
RF9
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Synonyms |
1-Adamantanecarbonyl-RF-NH2
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C26H38N6O3
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Canonical SMILES |
C1C2CC3CC1CC(C2)(C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CC=CC=C4)C(=O)N
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InChI |
1S/C26H38N6O3/c27-22(33)21(12-16-5-2-1-3-6-16)31-23(34)20(7-4-8-30-25(28)29)32-24(35)26-13-17-9-18(14-26)11-19(10-17)15-26/h1-3,5-6,17-21H,4,7-15H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30)/t17?,18?,19?,20-,21-,26?/m0/s1
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InChIKey |
UMKHUSRDQFQHAK-RNJMTYCLSA-N
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CAS Number |
CAS 876310-60-0
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PubChem Compound ID | ||||
PubChem Substance ID | ||||
ChEBI ID |
CHEBI:140980
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Target and Pathway | Top | |||
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Target(s) | Neuropeptide FF receptor 1 (NPFFR1) | Target Info | Antagonist | [2] |
Neuropeptide FF receptor 2 (NPFFR2) | Target Info | Antagonist | [2] |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1486). | |||
REF 2 | RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):466-71. |
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