Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D08UOW
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| Former ID |
DIB020385
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| Drug Name |
MMPIP
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| Synonyms |
mmpip hydrochloride; 479077-02-6; CHEMBL593489; 6-(4-methoxyphenyl)-5-methyl-3-(pyridin-4-yl)isoxazolo[4,5-c]pyridin-4(5H)-one; GTPL3341; SCHEMBL3014586; CTK8D4056; DTXSID90433202; MolPort-006-069-049; MMPIP, > BCP23933; BDBM50305877; ZINC34042470; BN0822; AKOS015851872; API0008470; NCGC00378759-01; QC-10186; KB-274653; S14-1930; 6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridyl)isoxazolo[4,5-c]pyridine-4(5H)-one; 6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[ 4,5-c]pyridin-4(5H)-one
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C19H15N3O3
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| Canonical SMILES |
CN1C(=CC2=C(C1=O)C(=NO2)C3=CC=NC=C3)C4=CC=C(C=C4)OC
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| InChI |
1S/C19H15N3O3/c1-22-15(12-3-5-14(24-2)6-4-12)11-16-17(19(22)23)18(21-25-16)13-7-9-20-10-8-13/h3-11H,1-2H3
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| InChIKey |
PDWYBOZNEVALOV-UHFFFAOYSA-N
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| CAS Number |
CAS 479077-02-6
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Metabotropic glutamate receptor 7 (mGluR7) | Target Info | Modulator (allosteric modulator) | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Glutamatergic synapse | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Metabotropic glutamate receptor group III pathway | ||||
| Reactome | G alpha (i) signalling events | |||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3341). | |||
| REF 2 | Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7. Mol Pharmacol. 2010 Mar;77(3):459-68. | |||
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