Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08RPN
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| Former ID |
DNC007631
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| Drug Name |
(4-bromo-1H-pyrazol-1-yl)(m-tolyl)methanone
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| Synonyms |
(4-bromo-1H-pyrazol-1-yl)(3-methylphenyl)methanone; AC1LDSCC; N-Benzoylpyrazole deriv., 22; CHEMBL397270; BDBM23714; ZINC37185; MolPort-002-705-233; STK662514; 4-bromopyrazolyl 3-methylphenyl ketone; AKOS005526022; MCULE-2046425213; ST033221; (4-bromopyrazol-1-yl)-(3-methylphenyl)methanone; SR-01000524314; 4-bromo-1-[(3-methylphenyl)carbonyl]-1H-pyrazole; SR-01000524314-1
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C11H9BrN2O
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| Canonical SMILES |
CC1=CC(=CC=C1)C(=O)N2C=C(C=N2)Br
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| InChI |
1S/C11H9BrN2O/c1-8-3-2-4-9(5-8)11(15)14-7-10(12)6-13-14/h2-7H,1H3
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| InChIKey |
WACJMZOPBBWBAJ-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neutrophil elastase (NE) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Transcriptional misregulation in cancer | |||
| Systemic lupus erythematosus | ||||
| Pathway Interaction Database | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | |||
| C-MYB transcription factor network | ||||
| Reactome | Collagen degradation | |||
| Degradation of the extracellular matrix | ||||
| Activation of Matrix Metalloproteinases | ||||
| WikiPathways | Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | |||
| Human Complement System | ||||
| Degradation of collagen | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. | |||
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