Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08PXL
|
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| Former ID |
DNCL003829
|
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| Drug Name |
MK-8457
|
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| Indication | Rheumatoid arthritis [ICD-11: FA20] | Phase 2 | [1] | |
| Company |
Merck
|
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| Structure |
 |
Download2D MOL |
||
| Formula |
C24H25F3N4O3S
|
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| Canonical SMILES |
CC1=CC(=CC(=C1)NC2=NC=CC(=N2)C(F)(F)F)C3=CN=C(S3)C4(CCC(C(C4)(C)C)C(=O)O)O
|
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| InChI |
1S/C24H25F3N4O3S/c1-13-8-14(10-15(9-13)30-21-28-7-5-18(31-21)24(25,26)27)17-11-29-20(35-17)23(34)6-4-16(19(32)33)22(2,3)12-23/h5,7-11,16,34H,4,6,12H2,1-3H3,(H,32,33)(H,28,30,31)/t16-,23-/m1/s1
|
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| InChIKey |
LDDBKIFZPGDEND-WAIKUNEKSA-N
|
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| PubChem Compound ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01569152) Safety and Efficacy of MK-8457 and Methotrexate (MTX) in Participants With Active Rheumatoid Arthritis Despite MTX Therapy (MK-8457-008). U.S. National Institutes of Health. | |||
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