Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08OJF
|
|||
| Former ID |
DCL000130
|
|||
| Drug Name |
ICA-105665
|
|||
| Indication | Epilepsy [ICD-11: 8A60-8A68] | Phase 2 | [1] | |
| Company |
Icagen
|
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Voltage-gated potassium channel Kv7.3 (KCNQ3) | Target Info | Activator | [2] |
| KEGG Pathway | Cholinergic synapse | |||
| Reactome | Voltage gated Potassium channels | |||
| Interaction between L1 and Ankyrins | ||||
| WikiPathways | Potassium Channels | |||
| L1CAM interactions | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Kv7 potassium channel activation with ICA-105665 reduces photoparoxysmal EEG responses in patients with epilepsy. Epilepsia. 2013 Aug;54(8):1437-43. | |||
| REF 2 | New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channels. Curr Neurol Neurosci Rep. 2008 Jul;8(4):345-52. | |||
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