Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08OFS
|
|||
| Former ID |
DNC009674
|
|||
| Drug Name |
5-fluoro-6-azido-UMP
|
|||
| Synonyms |
uridine derivative, 41; CHEMBL514166; SCHEMBL15189843; BDBM27944; {[(2R,3S,4R,5R)-5-(6-azido-5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C9H11FN5O9P
|
|||
| Canonical SMILES |
C(C1C(C(C(O1)N2C(=C(C(=O)NC2=O)F)N=[N+]=[N-])O)O)OP(=O)(O)O
|
|||
| InChI |
1S/C9H11FN5O9P/c10-3-6(13-14-11)15(9(19)12-7(3)18)8-5(17)4(16)2(24-8)1-23-25(20,21)22/h2,4-5,8,16-17H,1H2,(H,12,18,19)(H2,20,21,22)/t2-,4-,5-,8-/m1/s1
|
|||
| InChIKey |
ARRBQQMKVQEOHQ-UMMCILCDSA-N
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Orotidine 5'-monophosphate decarboxylase (UMPS) | Target Info | Inhibitor | [1] |
| BioCyc | Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis | |||
| Superpathway of pyrimidine ribonucleotides de novo biosynthesis | ||||
| UMP biosynthesis | ||||
| KEGG Pathway | Pyrimidine metabolism | |||
| Drug metabolism - other enzymes | ||||
| Metabolic pathways | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Reactome | Pyrimidine biosynthesis | |||
| WikiPathways | Metabolism of nucleotides | |||
| Fluoropyrimidine Activity | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J Med Chem. 2009 Mar 26;52(6):1648-58. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.