Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08ODH
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| Former ID |
DIB002306
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| Drug Name |
Atiratecan
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| Synonyms |
CH-0793011; CH-0793076; CH-4556300; TP-300
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| Drug Type |
Small molecular drug
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| Indication | Colorectal cancer [ICD-11: 2B91.Z] | Discontinued in Phase 2 | [1] | |
| Company |
Chugai Pharmaceutical Co Ltd
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| Structure |
 |
Download2D MOL |
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| Formula |
C31H34N6O6
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| Canonical SMILES |
CCCCCN1C=NC2=CC=CC3=C2C1=C4CN5C(=CC6=C(C5=O)COC(=O)C6(CC)OC(=O)CN(C)C(=O)CN)C4=N3
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| InChI |
1S/C31H34N6O6/c1-4-6-7-11-36-17-33-21-9-8-10-22-26(21)28(36)18-14-37-23(27(18)34-22)12-20-19(29(37)40)16-42-30(41)31(20,5-2)43-25(39)15-35(3)24(38)13-32/h8-10,12,17H,4-7,11,13-16,32H2,1-3H3/t31-/m0/s1
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| InChIKey |
CWJSAEZZZABNRI-HKBQPEDESA-N
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| CAS Number |
CAS 867063-97-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA topoisomerase I (TOP1) | Target Info | Inhibitor | [2] |
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | DNA replication | |||
| Pathway Interaction Database | Caspase Cascade in Apoptosis | |||
| WikiPathways | Integrated Pancreatic Cancer Pathway | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024385) | |||
| REF 2 | Method development and validation of the simultaneous determination of a novel topoisomerase 1 inhibitor, the prodrug, and the active metabolite in human plasma using column-switching LC-MS/MS, and its application in a clinical trial. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Nov 15;879(30):3415-22. | |||
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