Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08MTG
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| Former ID |
DIB003924
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| Drug Name |
Abafungin
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| Synonyms |
Abasol; W-634; YP-006; YP-007; Abafungin (gel formulation), York Pharma; Abafungin (cream, dermatomycosis), York Pharma; Abafungin (gel formulation, onychomycosis), York Pharma; Abafungin (pessary, vaginal candidiasis), York Pharma
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| Drug Type |
Small molecular drug
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| Indication | Fungal infection [ICD-11: 1F29-1F2F; ICD-10: B35-B49; ICD-9: 110-118] | Discontinued in Phase 3 | [1] | |
| Company |
York Pharma
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| Structure |
 |
Download2D MOL |
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| Formula |
C21H22N4OS
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| Canonical SMILES |
CC1=CC(=C(C=C1)OC2=CC=CC=C2C3=CSC(=N3)NC4=NCCCN4)C
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| InChI |
1S/C21H22N4OS/c1-14-8-9-18(15(2)12-14)26-19-7-4-3-6-16(19)17-13-27-21(24-17)25-20-22-10-5-11-23-20/h3-4,6-9,12-13H,5,10-11H2,1-2H3,(H2,22,23,24,25)
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| InChIKey |
TYBHXIFFPVFXQW-UHFFFAOYSA-N
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| CAS Number |
CAS 129639-79-8
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:76005
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Candida Cytochrome P450 51 (Candi ERG11) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022887) | |||
| REF 2 | Upregulation of sterol C14-demethylase expression in Trypanosoma cruzi treated with sterol biosynthesis inhibitors. Mol Biochem Parasitol. 2005 Nov;144(1):68-75. | |||
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