Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D08MJE
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| Former ID |
DNC010686
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| Drug Name |
(R,)-2-(2-naphthamido)-5-phenylpent-4-enoic acid
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| Synonyms |
CHEMBL1090714; (2R,4E)-2-[(naphthalen-2-ylcarbonyl)amino]-5-phenylpent-4-enoic acid; (R,)-2-(2-naphthamido)-5-phenylpent-4-enoic acid; SCHEMBL16550527; SCHEMBL16550525; BDBM50314705
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C22H19NO3
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| Canonical SMILES |
C1=CC=C(C=C1)C=CCC(C(=O)O)NC(=O)C2=CC3=CC=CC=C3C=C2
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| InChI |
1S/C22H19NO3/c24-21(19-14-13-17-10-4-5-11-18(17)15-19)23-20(22(25)26)12-6-9-16-7-2-1-3-8-16/h1-11,13-15,20H,12H2,(H,23,24)(H,25,26)/b9-6+/t20-/m1/s1
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| InChIKey |
OOTIJYFZZMIZHN-AQDCRGGLSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Rotamase Pin1 (PIN1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | RIG-I-like receptor signaling pathway | |||
| Pathway Interaction Database | p73 transcription factor network | |||
| C-MYC pathway | ||||
| PDGFR-beta signaling pathway | ||||
| p53 pathway | ||||
| Reactome | ISG15 antiviral mechanism | |||
| Negative regulators of RIG-I/MDA5 signaling | ||||
| WikiPathways | ISG15 antiviral mechanism | |||
| RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Structure-based design of novel human Pin1 inhibitors (II). Bioorg Med Chem Lett. 2010 Apr 1;20(7):2210-4. | |||
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