Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08LLM
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| Former ID |
DIB012009
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| Drug Name |
NS-8
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| Synonyms |
NS-8; 186033-14-7; 2-amino-3-cyano-4-methyl-5-(2-fluorophenyl)pyrrole; 2-amino-5-(2-fluorophenyl)-4-methyl-1H-pyrrole-3-carbonitrile; KVDWOQGDMAEJLM-UHFFFAOYSA-N; CHEMBL42661; SCHEMBL4624842; ZINC21886; MolPort-005-943-258; AKOS027201108; EN300-254366; 2-amino-3-cyano-4-methyl-5-(2fluorophenyl)pyrrole; Z2306534448
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| Drug Type |
Small molecular drug
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| Indication | Urinary incontinence [ICD-11: MF50.2; ICD-9: 788.3] | Phase 1 | [1] | |
| Company |
Nippon Shinyaku Co Ltd
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| Structure |
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Download2D MOL |
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| Formula |
C12H10FN3
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| Canonical SMILES |
CC1=C(NC(=C1C#N)N)C2=CC=CC=C2F
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| InChI |
1S/C12H10FN3/c1-7-9(6-14)12(15)16-11(7)8-4-2-3-5-10(8)13/h2-5,16H,15H2,1H3
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| InChIKey |
KVDWOQGDMAEJLM-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Potassium channel unspecific (KC) | Target Info | Agonist | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of Nippon Shinyaku Co Ltd. | |||
| REF 2 | Stimulation of large-conductance calcium-activated potassium channels inhibits neurogenic contraction of human bladder from patients with urinary symptoms and reverses acetic acid-induced bladder hyperactivity in rats. Eur J Pharmacol. 2014 Jul 15;735:68-76. | |||
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