Drug Information
Drug General Information | Top | |||
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Drug ID |
D08KCA
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Former ID |
DNC000872
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Drug Name |
Leupeptin
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Synonyms |
2-(2-Acetamido-4-methylvaleramido)-N-(1-formyl-4-guanidinobutyl)-4-methylvaleramide; AC1L97IT; Valeramide, 2-(2-acetamido-4-methylvaleramido)-N-(1-formyl-4-guanidinobutyl)-4-methyl-; 24365-55-7; (2S)-2-acetamido-N-[1-[[5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methylpentanamide
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Drug Type |
Small molecular drug
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Indication | Malaria [ICD-11: 1F40-1F45; ICD-10: B50-B64, B54] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C20H38N6O4
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Canonical SMILES |
CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C=O)NC(=O)C
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InChI |
1S/C20H38N6O4/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23)/t15-,16-,17-/m0/s1
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InChIKey |
GDBQQVLCIARPGH-ULQDDVLXSA-N
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CAS Number |
CAS 55123-66-5
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PubChem Compound ID | ||||
PubChem Substance ID | ||||
ChEBI ID |
CHEBI:6426
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Target and Pathway | Top | |||
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Target(s) | Plasmodium Cysteine protease falcipain (Malaria CPF) | Target Info | Inhibitor | [1] |
Plasmodium Cysteine protease falcipain-2 (Malaria CPF2) | Target Info | Inhibitor | [2] | |
Plasmodium Plasmepsin 1 (Malaria PLA1) | Target Info | Inhibitor | [1] | |
Plasmodium Plasmepsin 2 (Malaria PLA2) | Target Info | Inhibitor | [1] |
References | Top | |||
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REF 1 | Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10. | |||
REF 2 | Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97. |
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